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在青少年脊椎关节炎中炎症性肠病的患病率
Ipek Ulkersoy1, Umit Gul2, Mehmet Yildiz2
1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Journal of digestive diseases
|January 16, 2026
概括
便calprotectin (FCP) 的升高可能表明青少年脊髓关节炎 (JSpA) 的儿童的静音肠道炎症. 这种非侵入性标志物有助于在这些风险患者中早期检测炎症性肠病 (IBD).
科学领域:
- 儿科风湿病学 儿科风湿病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 青少年脊椎关节炎 (JSpA) 与儿科炎性肠病 (IBD) 有共同特征,增加了JSpA患者患IBD的风险.
- 在JSpA中早期发现IBD对于及时诊断和管理至关重要.
研究的目的:
- 为了确定患有JSpA的儿童中IBD的患病率.
- 为了在JSpA患者中确定IBD检测的早期,非侵入性标志物.
- 加强在JSpA中IBD的诊断,查和治疗策略.
主要方法:
- 对被诊断患有JSpA的儿童进行前性评估.
- 在所有参与者的便calprotectin (FCP) 的测量.
- 对那些患有升高的FCP或IBD相关症状的人进行了肠直肠镜检查,并进行了他的病理学和放射学评估.
主要成果:
- 17.3%的JSpA患者被诊断出患有大肠炎.
- 在19名儿童中发现FCP水平升高,其中68.4%的儿童表现出粘膜变化.
- 94.7%的高FCP儿童无症状IBD,突出FCP在检测亚临床炎症中的作用.
- 在FCP阳性和大肠炎阳性患者中,圣炎的发生频率更高.
结论:
- 炎症性肠病和亚临床结肠炎在青少年脊柱关节炎中很常见.
- 便calprotectin的升高是一个有价值的非侵入性生物标志物,用于检测JSpA.中的静音肠道炎症.
- 结肠膜镜检查是必要的,以确认由FCP水平升高所暗示的发现.
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