Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

682
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
682
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

242
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
242
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

338
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
338
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

249
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
249
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

1.9K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.9K
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

155
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
155

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

RBMX functional retrocopy safeguards brain development in a species-dependent context.

Brain : a journal of neurology·2026
Same author

PMX-CovEval: A Framework Including a Simulated Pharmacokinetic Database for Covariate Model Building Methods Benchmarking.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Cdk7 promotes neuritogenesis in cortical neurons and contributes to social behavior in mice.

Cellular and molecular life sciences : CMLS·2026
Same author

Developmental gene expression patterns driving species-specific cortical features.

Nature·2026
Same author

Protocol for whole-cell patch-clamp recording and post hoc identification of hippocampal CA2 pyramidal neurons in adult mouse brain slices.

STAR protocols·2026
Same author

Sex Differences and Survival Among COPD Patients in France: The Palomb Cohort.

International journal of chronic obstructive pulmonary disease·2026

相关实验视频

Updated: Jan 18, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.6K

整合人口方法与生理学基础的药动力学模型:参数估计的新框架.

Donato Teutonico1, David Marchionni2, Marc Lavielle3,4

  • 1Pharmacometrics, Translational Medicine Unit, Sanofi, Vitry-sur-Seine, France.

CPT: pharmacometrics & systems pharmacology
|January 16, 2026
PubMed
概括

这项研究为生理学基础药理动力学 (PBPK) 模型引入了一种新的人口方法,改进了参数估计和减少计算时间. 这种方法通过利用个人数据来提高药物开发,以获得更准确的药理动力学预测.

关键词:
PBPKK PBPK 的意思是什么意思这就是SAEMEM的意义.个体的变化,个体的变化.基于生理学的药理动力学.popPBPKK popPBPKK 这是一个很大的问题popWB-PBPK 在线播放

更多相关视频

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
10:02

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

33.3K
Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.8K

相关实验视频

Last Updated: Jan 18, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.6K
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
10:02

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

33.3K
Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.8K

科学领域:

  • 药理动力学和药物开发
  • 计算生物学和生物信息学
  • 系统药理学系统药理学

背景情况:

  • 生理学基础的药理动力学 (PBPK) 建模对于预测开发过程中的药物度至关重要.
  • 在PBPK模型中估计参数是具有挑战性的,因为参数众多,数据有限.
  • 现有的方法很难有效地估计生理学相关参数的个体间变异性.

研究的目的:

  • 为增强参数估计引入一种新型的人口全身PBPK (popWB-PBPK) 建模方法.
  • 为了利用个体患者数据,更准确地进行PBPK模型参数化和可变性评估.
  • 提出一个优化的随机近似预期-最大化 (SAEM) 算法,用于高效的PBPK参数估计.

主要方法:

  • 将全身PBPK (WB-PBPK) 模型与人口估计技术结合起来.
  • 实现一个优化的SAEM算法与自适应参数网格优化和线性插值.
  • 使用theophylline作为一个案例研究来估计药物特异性参数和共变效应 (例如,吸烟状态).

主要成果:

  • popWB-PBPK方法准确地估计了药物特定的参数,如CYP1A2清除率和脂性.
  • 与标准SAEM相比,优化的SAEM算法显著减少了计算运行时间.
  • 该方法成功地结合了共变量效应,证明了其实际实用性.

结论:

  • 开发的popWB-PBPK框架提供了一个可访问的R包 (saemixPBPK),用于可靠的PBPK参数估计.
  • 这种方法可以同时估计种群参数,可变性和不确定性,同时保持生理相关性.
  • 机械模型的进步使得使用个人数据进行更可靠的药理动力学预测.