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Updated: Jan 18, 2026

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
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一个基于机制的多层次人群PK/PD模型,用于竞争性酸阻塞剂

Woojin Jung1,2, Jaeyeon Lee3, Hyeseon Jeon1

  • 1College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, Republic of Korea.

CPT: pharmacometrics & systems pharmacology
|January 16, 2026
PubMed
概括

优化竞争性酸阻断剂 (PCAB) 的剂量是复杂的. 一个新的模型揭示了食物摄入量和药物特性如何影响PCAB疗效,有助于针对酸性疾病的个性化治疗策略.

关键词:
这是一种抗的抗剂.多层次的人口分析.这就是法拉摩动力学.药物动力学 药物动力学药学指标 药学指标 药学指标 药学指标

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Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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