使用与儿童注意力问题相关的面部形态特征来确定产前暴露史
Anna Shchetinina1, Xianjing Liu2,3, Natalie Slopen1
1Department of Social and Behavioral Sciences, https://ror.org/03vek6s52Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Journal of developmental origins of health and disease
|January 16, 2026
概括
儿童的面部形状可能表明与产前暴露有关的神经发育问题. 特定的面部特征与注意力问题相关,为早期发展影响提供了见解.
科学领域:
- 神经发育生物学 神经发育生物学
- 医疗成像医学成像
- 遗传学 遗传学 是一个
背景情况:
- 大脑发育和面部形态都有共同的胚胎起源.
- 产前暴露会影响神经发育,并可能影响面部特征.
研究的目的:
- 调查儿童的面部参数是否可以揭示产前暴露的神经发育影响.
- 探索面部形态,儿童行为和产前因素之间的关联.
主要方法:
- 利用人工智能和3D面部成像分析了2,779名儿童 (9-10岁) 的形态.
- 检查了面部特征和行为结果 (内化,外化,注意力问题) 之间的相关性.
- 通过回归分析评估特定产前暴露 (物质,微量营养素) 和面部特征之间的关系.
主要成果:
- 一个明显的面部特征 (下巴回退,鼻子变异,不对称) 与注意力问题密切相关.
- 产前维生素D和叶酸含量较高与增加的面部曲率有关.
- 产前吸烟与面部曲有负面关联.
结论:
- 面部形态可以作为神经外皮发育障碍的生物标志物.
- 面部分析有助于理解产前暴露对神经发育和行为的影响.
- 母亲吸烟,维生素D和叶酸水平影响面部形态,反映了发育起源.
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