Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

9.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Circulating Tumor DNA Status and Adjuvant Chemotherapy in Resected Colorectal Liver Metastases.

JAMA oncology·2026
Same author

Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.

Pediatric pulmonology·2026
Same author

Prognostic Implications of Personalized Circulating Tumor DNA Testing in Patients with Advanced Urothelial Carcinoma Treated with Enfortumab Vedotin ± Pembrolizumab.

European urology oncology·2026
Same author

Overview of the linking exercise for advancing daily stress (LEADS) management and resilience randomized controlled trial in African American families.

Contemporary clinical trials·2026
Same author

Efficacy of Less Invasive Surfactant Administration (LISA) in Preterm Neonates With Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.

Sage open pediatrics·2026
Same author

Post-adjuvant chemotherapy in ctDNA-positive patients with resected colorectal cancer: a randomized phase 3 trial.

Nature medicine·2026
Same journal

Development of CypriSSR: a genome-wide, chromosome-level microsatellite database for multiple cyprinidae species.

Database : the journal of biological databases and curation·2026
Same journal

KitBase Expanded: An Integrated Genomic and Phenotypic Resource for 3,268 Fast-Neutron-Irradiated Rice Mutants.

Database : the journal of biological databases and curation·2026
Same journal

PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery.

Database : the journal of biological databases and curation·2026
Same journal

A similarity metric, rubric, and unified hierarchy for biomedical publication types and study designs.

Database : the journal of biological databases and curation·2026
Same journal

GUTAID: a curated database linking gut microbial antigens to autoimmune mechanisms.

Database : the journal of biological databases and curation·2026
Same journal

Rosetta Statements: simplifying FAIR knowledge graph construction with a user-centred approach.

Database : the journal of biological databases and curation·2026
查看所有相关文章

相关实验视频

Updated: Jan 18, 2026

Author Spotlight: Advancing Tear Fluid Analysis Using a Standardized Protocol for Proteomics Research
08:20

Author Spotlight: Advancing Tear Fluid Analysis Using a Standardized Protocol for Proteomics Research

Published on: December 1, 2023

3.1K

眼液数据库:眼液蛋白学参考网站.

Drew Mayernik1, Saleh Ahmed1, Eliza Williams1

  • 1Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.

Database : the journal of biological databases and curation
|January 16, 2026
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种敏感的质谱法来分析人类的液蛋白质组,在每个样本中识别出1000多种蛋白质. 这项工作建立了一个基础数据库,用于发现疾病生物标志物和理解眼生物学.

更多相关视频

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research
09:04

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research

Published on: July 19, 2024

2.4K
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
09:22

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles

Published on: October 13, 2017

12.3K

相关实验视频

Last Updated: Jan 18, 2026

Author Spotlight: Advancing Tear Fluid Analysis Using a Standardized Protocol for Proteomics Research
08:20

Author Spotlight: Advancing Tear Fluid Analysis Using a Standardized Protocol for Proteomics Research

Published on: December 1, 2023

3.1K
Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research
09:04

Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research

Published on: July 19, 2024

2.4K
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
09:22

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles

Published on: October 13, 2017

12.3K

科学领域:

  • 生物化学 生物化学
  • 蛋白质组学是指蛋白质组学.
  • 眼科医生 眼科 眼科

背景情况:

  • 液蛋白质组分析对于识别眼部和全身疾病生物标志物至关重要.
  • 小小的撕裂样本体积对高质量的蛋白质组数据采集构成了挑战.
  • 眼液现有的蛋白质组数据集是有限的.

研究的目的:

  • 开发一种高度敏感的质谱工作流程,用于人类眼液的蛋白质分析.
  • 创建一个全面的人类液蛋白质组数据库,并附有临床注释.
  • 为了确定常见检测到的液蛋白的参考丰度范围.

主要方法:

  • 开发一个敏感的质谱 (MS) 工作流程.
  • 分析了74个个人的眼液样本.
  • 创建一个用户友好的在线数据库 (TearFluid数据库) 用于数据探索.

主要成果:

  • 从单个眼样本中鉴定出超过1000种蛋白质.
  • 人类液蛋白质组的全面分析,包括2,134种独特的蛋白质.
  • 确定眼液蛋白的参考丰度范围.

结论:

  • 开发的MS工作流程能够进行强大的液蛋白质组分析.
  • 眼流体数据库是生物标志物发现和眼生物学研究的宝贵资源.
  • 该资源将加速与疾病相关的蛋白质组特征和临床相关生物标志物的识别.