以色列住院患者中肠道病毒流行病学 (2016-2024):中枢神经系统参与,亚型变化和季节性
Ilana S Fratty1,2, Or Kriger3,4, Leah Weiss1
1Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel.
肠道病毒 (EV) 引起各种疾病. 这项研究跟踪了以色列EV分子流行病学,发现季节性和基因型的变化,SARS-CoV-2影响了循环.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肠道病毒 (EV) 是重要的人类病原体,引起一系列疾病,从轻微的发烧性疾病到严重的神经并发症.
- 了解电动汽车的分子流行病学,临床影响和季节性对于有效的公共卫生监测和干预策略至关重要.
研究的目的:
- 评估以色列住院患者的肠道病毒 (EV) 的分子流行病学,临床影响和季节性.
- 为了确定常见的EV基因型,跟踪季节性模式,并评估SARS-CoV-2流行病对EV循环的影响.
- 分析流行EV亚型的基因组变异及其与疾病严重程度的关联,特别是在婴儿中.
主要方法:
- 从2016年至2024年期间从住院患者收集的11,246个脑脊液 (CSF) 和5,744个便样本的回顾性分析.
- 实时逆转录聚合酶连锁反应 (RT-PCR) 用于EV RNA检测.
- 部分VP1基因测序用于EV基因型识别和遗传学分析.
主要成果:
- 在7.1%的脊髓液样本和19.3%的便样本中检测到EVRNA.
- 最常见的CSF亚型包括E-18,E-5,E-6,E-30,CVB5,E-4和CVB2.
- 季节性分析揭示了预期的夏季高峰,但也有意料之外的季节性疫情和在SARS-CoV-2大流行期间的EV阳性显著下降,随后是复苏.
- 遗传学分析表明CVB2,E-5,E-6,E-18和E-30中的基因组变化.
- 肠道病毒-B (CVB2) 感染与严重的婴儿疾病有关,10.6%的测序病例需要接受ICU治疗.
结论:
- 以色列的肠道病毒流行病学表现出动态变化,包括季节性变化和基因型分布.
- SARS-CoV-2 流行病显著影响了 EV 循环模式,需要持续的分子监测.
- 识别新出现的EV菌株和了解流行病学趋势对于公共卫生准备和应对至关重要.
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