检查酒精使用障碍和玻璃眼之间的关系:范围审查协议
Fatima Elghazali1, Alexandria Hughes1, Tracy Shields2
1Translational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.
JMIR research protocols
|January 16, 2026
概括
本范围审查审查考察了酒精使用障碍 (AUD) 和玻璃眼之间的复杂关系. 它旨在澄清有关酒精消费如何影响青光眼的发展和进展的混合发现.
科学领域:
- 眼科医生 眼科 眼科
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
背景情况:
- 酒精使用障碍 (AUD) 影响包括眼睛在内的各种器官系统,对眼内压力 (IOP) 有潜在的剂量依赖影响.
- 现有的关于酒精与青光眼之间的联系的研究结果各不相同,特别是在AUD人群中进行的调查有限.
- 玻璃眼症的特点是视神经受损和视力丧失,可能受到与大量饮酒相关的系统性变化的影响.
研究的目的:
- 进行范围审查,综合有关饮酒,AUD和玻璃眼的当前文献.
- 绘制现有研究的地图,确定酒精摄入量与青光眼之间的关联,并综合有关饮酒模式和青光眼风险的证据.
- 澄清AUD和玻璃眼之间的关系,以告知未来的研究方向.
主要方法:
- 在主要的生物医学数据库 (PubMed,MEDLINE,Embase,Web of Science,CENTRAL) 进行系统的文献搜索.
- 采用Covidence软件的两步选过程,由两名研究人员进行独立审查.
- 数据图表和证据综合呈现在叙事和表格格式.
主要成果:
- 该审查目前正在进行中,于2024年11月启动.
- 数据收集和提交预计将在2025年11月至2026年1月之间完成.
- 资金由国家卫生研究院内部研究计划提供.
结论:
- 这一范围审查将全面概述有关酒精消费和青光眼的文献.
- 预计这些发现将澄清不一致的研究结果,并指导未来对AUD及其眼部表现的调查.
- 这项研究旨在增强对酒精使用如何影响青光眼的发展和进展的理解.
相关概念视频
01:25Glaucoma: Overview
1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
01:27Open Angle Glaucoma: Treatment
963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
01:28Angle Closure Glaucoma: Treatment
1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K