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在法国和冈比亚 (Inci-D) 慢性乙型肝炎病毒感染者中,肝炎D病毒血清转化率

Patrick Ingiliz^1,2, Erwan Vo Quang^1,2,3, Gibril Ndow³

¹Hepatology Department, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.

Open forum infectious diseases

|January 16, 2026

概括

型肝炎病毒 (HDV) 超级感染在乙型肝炎病毒 (HBV) 阳性个体中很常见. 在Inci-D研究中,在冈比亚和法国发现了显著的高密度病毒超级感染率,支持对HBsAg载体进行常规的高密度病毒检测.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
流行病学流行病学

背景情况:

乙型肝炎病毒 (HDV) 的超级感染加剧了慢性乙型肝炎 (HBV) 的进展.
目前的国际指导方针不建议对HBV表面抗原 (HBsAg) 阳性个体进行常规的HDV检测.
在双重感染个体中,高强度病毒超级感染的时间尚不清楚.

研究的目的:

评估HBsAg阳性个体中高密度病毒超级感染的发生率.
分析不同地理群体的高密度病毒超级感染发病率.

主要方法:

在Inci-D研究中,分析了来自冈比亚和法国的两个潜在HBV队伍的血样本和干血斑点.
总共有1016名HBsAg阳性个体被评估为HDV抗体.
随访持续时间各不相同,冈比亚的中位数为5.98年,法国的中位数为2.1年.

主要成果:

冈比亚的基线HDV患病率为1.1%,法国为2.5%.
新发现的HDV抗体阳性病例发生在冈比亚的每1000个患者年3.85个,法国的每1000个患者年3.70个.
冈比亚和法国队伍之间的人口和临床特征有所不同.

结论:

在冈比亚和法国的HBsAg阳性载体中,型肝炎的超级感染发生率相当高.
这些发现支持在HBsAg阳性个体中考虑重复的HDV血清测试.
常规的HDV检测可以帮助识别双重感染的患者进行适当的管理.

关键词:

欧洲欧洲欧洲欧洲欧洲欧洲欧洲这是一种HBV-HDV共感染.西非西非是西非的一个地区.甲型肝炎甲型肝炎甲型肝炎查检查查检查查检查查检查传输传输传输传输传输传输

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