对炎症性血液蛋白质的环境温度暴露 - - 在瑞典年轻成年人的纵向自取样调查
Zhebin Yu1, Sophia Björkander2, Annika Bendes3
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
iScience
|January 16, 2026
概括
暴露于环境温度会通过改变与炎症相关的蛋白质对健康产生影响. 这项研究揭示了与肺功能,血压和蛋白质衰老加速相关的温度相关蛋白质.
科学领域:
- 环境健康 环境健康
- 蛋白质组学是指蛋白质组学.
- 生物标志物 生物标志物
背景情况:
- 连接温度暴露与健康结果的机制尚未完全理解.
- 炎症在各种健康状况中起着关键作用.
- 环境温度波动是一个全球环境因素.
研究的目的:
- 调查环境温度暴露与与炎症相关的蛋白质之间的关联.
- 探索性,吸烟和空气污染等因素如何改变这些关联.
- 确定温度相关蛋白与特定健康指标之间的关系.
主要方法:
- 从瑞典BAMSE队列 (2020-2022) 的807名参与者中收集了重复的干血点样.
- 使用高分辨率的时空模型来估计每日个体水平的温度暴露.
- 分析了365种与炎症相关的蛋白质,并在英国生物库中验证了这些发现.
主要成果:
- 58% (16%) 的受研究的与炎症相关的蛋白质与短期环境温度暴露有显著的关联.
- 温度效应受到性别,吸烟,喘和空气污染的改变.
- 与温度相关的蛋白质与肺功能,血压和HbA1c相关;高峰温度暴露增加了蛋白质衰老加速.
结论:
- 暴露于环境温度可以通过破坏与炎症相关的蛋白质对健康产生不利影响.
- 温度诱导的蛋白质组变化可能有助于加速衰老.
- 研究结果强调了在环境健康研究和临床实践中考虑温度的重要性.
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