富含多的植物性食物偏好及其对炎症性肠病的因果作用
Tinghui Yue1, Qiang Su1, Song He2
1The First Clinical Medical College Guizhou University of Traditional Chinese Medicine Guiyang Guizhou China.
Food science & nutrition
|January 16, 2026
概括
对富含多的食物 (如汁和豆) 的饮食偏好可能会防止克罗恩氏病 (CD). 相反,青菜的偏好与性结肠炎 (UC) 风险的增加有关,这表明多醇.
科学领域:
- 遗传学和营养流行病学
- 研究饮食偏好的遗传基础及其与复杂疾病的因果关系.
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是一个日益严重的全球健康问题.
- 饮食中的多醇具有抗炎和抗氧化特性,对慢性炎症状况有益.
- 对富含多的食物的饮食偏好在IBD病因学中的特定作用需要进一步阐明.
研究的目的:
- 探索对富含多的植物性食品的偏好与患UC和CD的风险之间的潜在因果关系.
- 使用遗传数据识别与IBD亚型相关的特定饮食偏好.
主要方法:
- 利用两样本的孟德尔随机化 (MR) 与全基因组关联研究 (GWAS) 的总结统计数据,用于65种植物性食物偏好和IBD亚型 (UC和CD).
- 采用逆方差加权 (IVW),MR-Egger和加权中位数方法进行因果推理.
- 进行了广泛的灵敏度分析 (科克兰的Q,MR-Egger拦截,MR-PRESSO,留出一个) 和施泰格过以获得稳定性.
- 应用多变量MR (MVMR) 和局部化分析来评估直接影响和共享的遗传架构.
主要成果:
- 在偏好富含多的植物性食品和IBD风险之间发现了显著的遗传关联.
- 偏爱汁和豆/豆类显示出对CD的保护作用 (分别为OR:0.329,P=0.007;OR:0.178,P=0.010).
- 青菜偏好与UC风险增加有关 (OR:3.942,P=0.039),而西瓜偏好与CD风险降低有关 (OR:0.168,P=0.039).
- 局部化分析显示,UC和香种的偏好之间有共同的遗传信号 (PP.H4=99.52%).
结论:
- 遗传证据支持偏好多丰富的植物性食品在调节IBD风险方面的因果关系.
- 饮食中的多可能通过肠道微生物群调节,增强肠道屏障功能和免疫反应调节产生保护作用.
- 研究结果强调了针对性饮食干预和改善疾病查的潜力,以预防和管理IBD.
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