针对性益生菌对通过调节肠道微生物群和代谢物的麻醉引起的睡眠障碍的影响
Rui-Zhi Yang1,2,3, Song Lin1,2, Le-Tong Huang1,2
1Department of Anesthesiology The First Affiliated Hospital of Fujian Medical University Fuzhou China.
Food science & nutrition
|January 16, 2026
概括
向性益生菌治疗通过恢复肠道细菌和减少与唤醒相关的代谢物,改善了老鼠的麻醉后睡眠质量. 这表明益生菌可能有助于缓解麻醉后的睡眠障碍.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 麻醉后的睡眠障碍会对患者的康复和福祉产生负面影响.
- 益生菌显示了通过肠道微生物群调节来改善睡眠的潜力.
- 麻醉可以破坏肠道和肺部的微生物平衡,可能会影响睡眠.
研究的目的:
- 调查针对性益生菌补充剂在缓解麻醉引起的睡眠障碍方面的有效性.
- 分析益生菌对肠道和肺部微生物群的影响以及麻醉后的代谢物概况.
- 探索肠道微生物群组成和与睡眠相关的代谢物之间的相关性.
主要方法:
- 雄性斯普拉格-道利大鼠被暴露在异氨酸麻醉中,并用含有或不含益生菌的酸奶 (乳酸菌和双菌) 治疗.
- 进行了长达7天的多睡眠记录,以评估睡眠模式.
- 16S rRNA测序和非向代谢分析了便和支气管支气管洗液 (BALF) 样本.
主要成果:
- 异氨酸麻醉诱导睡眠障碍和减少有益的肠道细菌 (乳酸菌,双菌).
- 益生菌治疗显著改善了麻醉后的睡眠质量,并增加了有益的肠道细菌的丰富性.
- 益生菌调节肠道和肺部代谢物,减少与唤醒相关的化合物,并与有益的植物有负相关性.
结论:
- 有针对性的益生菌干预有效地缓解了麻醉后的睡眠障碍.
- 益生菌治疗调节肠道和肺部微生物群及其相关代谢物.
- 在周围麻醉中服用益生菌是治疗睡眠障碍的潜在策略,需要进一步的临床研究.
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