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Updated: Jan 18, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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聚A-GLM:使用基因组语言模型进行 De novo 聚亚脱位预测的综合框架

Sourav Saha1, Naima Ahmed Fahmi1, Jeongsik Yong2

  • 1Department of Computer Science, University of Central Florida, Orlando, FL, USA.

Computational and structural biotechnology journal
|January 16, 2026
PubMed
概括

基因组语言模型 (GLMs) 准确地预测了多基化 (poly(A)) 位点,这对于基因表达调节至关重要. 这项研究介绍了PolyA-GLM,一个管道增强RNA处理见解的管道.

关键词:
跨物种测试 跨物种测试预测De novo聚亚脱位的预测有几次射击学习学习.基因组语言模型转录后的监管 转录后的监管变压器模型变压器模型

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相关概念视频

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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