复发性轨道转移在复合人体甲状腺激素后的毛囊变体乳头甲状腺癌中的复发性轨道转移
Eiman Ibrahim1, Lilamani Kurukulasuriya1, Tabitha Galloway2
1Department of Endocrinology, University of Missouri School of Medicine, Columbia, MO 65201, USA.
JCEM case reports
|January 16, 2026
概括
再组合人类甲状腺激素 (rhTSH) 可以导致症状性瘤扩张,即使是先前治疗过的转移. 这一案例凸显了接受rhTSH治疗的卵泡变异乳头甲状腺癌 (FVPTC) 患者的不良事件风险.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
背景情况:
- 复合人体甲状腺激素 (rhTSH) 是对差异化甲状腺癌的标准治疗方法.
- 虽然通常是安全的,但症状性瘤扩张是一种已知的,尽管罕见的不良影响.
- 以前的报道通常涉及具有已知的转移的侵袭性瘤变体.
研究的目的:
- 报告一个毛囊变体乳头甲状腺癌 (FVPTC) 的病例,在施用rhTSH后,轨道转移经历了症状扩张.
- 为了突出与治疗后复发转移的患者中与rhTSH相关的潜在风险.
主要方法:
- 一个患有循环轨道FVPTC转移的患者的病例报告.
- 用于诊断或治疗目的的rhTSH的管理.
- 临床评估,成像 (包括-131扫描) 和活检用于诊断和监测.
- 手术干预 (轨道切除和核切除).
主要成果:
- 患者在第二剂rhTSH后出现了右眼亡和轨道.
- -131扫描显示右轨道的强烈吸收与内延伸.
- 活检证实了FVPTC,患者需要手术管理.
结论:
- 在 rhTSH 之后,症状性瘤扩张甚至可以发生在先前治疗过的转移的情况下.
- 毛囊变异的乳头甲状腺癌与轨道干扰具有对rhTSH的不良反应的潜在风险.
- 当在有转移性疾病史的患者中使用rhTSH时,仔细选择和监测患者至关重要.
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