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Updated: Jan 18, 2026

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

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天体细胞对神经元进行NeuroD1重编程,用于修复犬类中风

Isaac H Clark1,2,3, Zachary Roushdy2, Dilmareth Natera-Rodriguez2,3

  • 1Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN, United States.

Frontiers in stroke
|January 16, 2026
PubMed
概括

这项研究探讨了将星球细胞重新编程为神经元,以治疗狗的缺血性中风. 接受治疗的狗表现出更好的功能恢复和减少大脑损伤,这表明有希望的治疗途径.

关键词:
这是一个神经D1D1的过程.腺相关载体 (AAV) 是一种星球细胞是星球细胞.狗类犬类动物 狗类犬类一次性中风中风中风中风中风

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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