潘塞翁-DNA:多功能编码解码系统,集成适应性NGS预处理算法,用于DNA数据存储
Adriano Galindo Leal1, Thiago Yuji Aoyagi1, André Guilherme Costa-Martins1
1Artificial Intelligence and Analytics Department, Institute for Technological Research, São Paulo, 05508-901, SP, Brazil.
Computational and structural biotechnology journal
|January 16, 2026
概括
Pantheon-DNA是DNA数据存储的新管道,可以高效地处理大型数据集. 它实现了高数据可检索性,并使用新的方法来防止DNA序列编码和检索过程中的错误.
科学领域:
- 生物技术是生物技术.
- 生物信息学是一种生物信息学.
- 数据存储数据存储数据存储
背景情况:
- DNA数据存储提供了高密度,但面临着可扩展性和错误挑战.
- 重复的DNA序列可能会导致分子级别的错误,并使数据处理复杂化.
- 从DNA中有效管理和检索大型数据集对于实际应用至关重要.
研究的目的:
- 介绍Pantheon-DNA,一个端到端的处理管道用于DNA数据存储.
- 解决DNA数据存储系统的可扩展性和效率挑战.
- 提高基于DNA的数据存储中的数据可检索性和可靠性.
主要方法:
- 开发了一个数据排列方案和随机化程序,以防止有问题的DNA序列模式.
- 实现了块数据架构,以增强并行处理和检索.
- 利用编码数据结构的先前知识来简化预处理和减少计算复杂性.
主要成果:
- 在低错误率 (LER) 和高错误率 (HER) 条件下,在10倍覆盖率下实现≥99.996%的数据可检索性.
- 在合成和测序实验中,成功编码和解码了1.59 MB的数据,其中包含多个文件.
- 通过预处理管道演示了减少计算复杂性和简化集群程序.
结论:
- 潘提昂-DNA有效地解决了DNA数据存储的可扩展性和效率.
- 提出的方法提高了通过实验结果验证的数据可靠性和可检索性.
- 未来的工作重点是改进错误纠正,特别是用于indel恢复,并优化预处理.
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