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Updated: Jan 18, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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TDP-43功能障碍导致密码可转移元素衍生的外原体 (crypTEs) 在iPSC衍生的神经元和ALS/FTD患者组织中积累

Isobel Bolger, Regina Shaw, Oliver H Tam

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    概括

    TDP-43蛋白质功能障碍导致神经元中的神秘基因-TE融合,扩大已知的RNA处理错误. 这些新的转录与ALS和认知衰退有关,揭示了疾病的新机制.

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