杏仁体连接性和儿童经历的歧视之间的关联
bioRxiv : the preprint server for biology
|January 16, 2026
概括
早期生活感知歧视 (PD) 与大脑变化有关. 在儿童中,较大的PD预测了杏仁体与丘脑的连接性发生变化,这表明未来健康风险的途径.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 歧视是一个重要的慢性压力因素,有记录的不良健康结果,特别是在种族和民族少数群体中.
- 早期的生活经历,包括歧视,可以塑造大脑发育,并可能影响长期健康轨迹.
- 了解将童年歧视与健康联系起来的神经机制对于干预和预防策略至关重要.
研究的目的:
- 调查儿童感知歧视 (PD) 与大脑连接之间的关联.
- 探索PD如何与桃体与关键大脑网络的连接关系,包括突出网络 (SN),默认模式网络 (DMN) 和乳头.
- 检查这些关联中的潜在调节因素,如创伤经历,特别是在多样化的子样本中.
主要方法:
- 利用了来自青少年大脑和认知发展 (ABCD) 研究®的4512名儿童 (9-11岁) 的数据.
- 采用线性混合效应模型来评估年轻人自我报告的PD和杏仁体休息状态fMRI连接 (AC) 之间的关系.
- 进行了二次分析,以评估环境和行为因素作为完整样本和BIPOC子样本中的调节者 (N = 1567).
主要成果:
- 在总体样本中,较高水平的感知歧视 (PD) 与桃体与右丘脑的连接性 (AC) 的增加显著相关.
- 在BIPOC亚样本中,发现了一种显著的相互作用:创伤经历缓解了PD-AC与前带皮层 (ACC; SN) 的联系.
- 具体来说,更大的创伤经历放大了PD和AC与ACC之间的积极关联.
结论:
- 在生命早期感知到的歧视会影响神经连接,特别是影响杏仁体与质体的连接,在脆弱的子组中,ACC.
- 这些发现强调了歧视是影响儿童时期大脑发育的关键因素.
- 结果强调了在心理病理风险的背景下考虑歧视的神经生物学影响的重要性.
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