使用古代DNA推断的自然选择的全球模式
bioRxiv : the preprint server for biology
|January 16, 2026
概括
古代DNA揭示了全球人口之间广泛的平行适应,随着时间的推移选择压力变化,影响着色素和免疫等特征. 这项研究扩大了我们对人类进化超越欧洲的理解.
科学领域:
- 人类进化人类进化
- 人口遗传学 人口遗传学
- 古代的基因组学 古代的基因组学
背景情况:
- 关于自然选择的古代DNA研究主要集中在欧洲人群上.
- 全球适应原理和局部选择性压力在各种人类祖先中仍未得到充分研究.
研究的目的:
- 通过使用古老的DNA,在全球5个地区的7244个个体中调查全基因组选择信号.
- 识别共同的和特定区域的适应,并了解随着时间的推移选择是如何变化的.
主要方法:
- 对来自欧洲,东亚,南亚,非洲和美洲的13个古老和19个现代人口的古老DNA进行分析.
- 应用多种统计方法来计算复杂的人口统计历史.
- 开发添加剂意识时间序列和多基因选择试验.
主要成果:
- 识别了31个全基因组显著的选择信号,包括新的位置.
- 有证据表明,在不同地区有广泛的并行或共享的适应.
- 证明随着时间的推移动态选择的变化 (例如,欧洲的LCT,东亚的ADH1B) 和对色素/免疫特征的定向选择.
结论:
- 人类的适应是一种广泛的现象,在各大洲都有显著的平行进化事件.
- 对于腰比率等特征的选择压力似乎是普遍的,这表明了基本的形态约束.
- 古代DNA分析为全球人类适应的节奏和模式提供了关键的见解.
相关概念视频
The Evidence for Evolution
47.6K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.6K
Evolutionary Relationships through Genome Comparisons
6.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.9K
Gene Evolution - Fast or Slow?
8.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
8.0K
Gene Evolution - Fast or Slow?
3.4K
3.4K
Limits to Natural Selection
34.0K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
34.0K
Natural Selection and Mating Preferences
483
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
Females, due to their biological roles in conception, pregnancy, and nursing,...
483


