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Updated: Jan 18, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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在PARP1中,SPRTN通过一个保守的多ADP - 核糖酶结合域来招募SPRTN进行DNA - 蛋白交叉链接

Katelyn Hurley, Liam P Leary, Martin Garcia

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    概括

    聚基聚合酶 (PARP1/2) 检测DNA-蛋白质交叉链接 (DPC) 并发出修复的信号. 这一发现揭示了PARP1/2作为DPC传感器和SPRTN作为第一个PARP导向蛋白酶.

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