皮层和thalamic起源的融合自由行为调制小鼠初级视觉皮层
bioRxiv : the preprint server for biology
|January 16, 2026
概括
没有指导的动物行为会影响感官处理. 这项研究揭示了面部运动和视觉刺激如何汇聚在小鼠的初级视觉皮层 (V1),整合了自上而下的和自下而上的途径.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 皮层电路中的皮层电路.
背景情况:
- 没有指导的动物行为可以影响感官信息流.
- 将感官输入与自发行为集成的神经回路尚未得到充分理解.
研究的目的:
- 研究小鼠初级视觉皮层 (V1) 中感官信息和未受指导的面部运动的融合.
- 为了确定参与这种集成的特定电路路径.
主要方法:
- 对V1皮层神经元和侧生殖细胞核 (LGN) 结合的双光子成像.
- 在视觉刺激期间,同时测量小鼠的面部运动.
- 对虚假的相关性进行控制,以分析神经活动模式.
主要成果:
- 在格子刺激过程中,在LGN boutons和V1皮层神经元中发现了眼睛运动和非眼部面部运动的表现.
- 在格刺激过程中,V1神经活动和面部运动之间的相关性比在空白刺激过程中更强.
- 这表明,在视觉处理过程中,LGN输入和高层大脑中心调制的整合.
结论:
- 初级视觉皮层 (V1) 将视觉刺激与未受指导的非视觉信号集成在一起.
- 一个持续的自上而下路径和一个刺激门的自下而上路径的融合存在于V1.
- 这种整合可能会在自然主义行为过程中塑造感官信息处理.
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