胎儿网络可控性与突触发育共同发展,并在怀孕期间与母亲网络可控性同步.
bioRxiv : the preprint server for biology
|January 16, 2026
概括
胎儿大脑发育显示出U形的可控性曲线,在妊娠35周左右达到最低. 这种轨迹与突触发育有关,与怀孕期间母亲大脑的变化相反相关.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 网络科学 网络科学
背景情况:
- 胎儿时期的白质发育对于认知功能至关重要.
- 胎儿大脑发育,网络可控性和认知能力之间的关系尚未得到充分理解.
研究的目的:
- 通过使用网络控制理论 (NCT) 来研究从第二季度到产后第一个月的大脑网络可控性的发展轨迹.
- 探索胎儿可控性,突触发育和怀孕期间母亲可控性之间的关系.
主要方法:
- 对胎儿和婴儿的结构连接数据的分析 (发展人类连接组项目).
- 应用网络控制理论 (NCT) 来评估整个大脑的可控性.
- 对胎儿基因表达数据和非人类灵长类动物正子发射断层扫描 (PET) 扫描突触密度的分析.
- 在怀孕期间对母亲大脑可控性的纵向映射.
主要成果:
- 在胎儿中发现了全脑可控的非线性U形发育曲线,最少在妊娠35周左右.
- 过早分娩改变了这些轨迹,显示出更大的可控性和更早的最小值.
- 胎儿突触功能与可控制性共同发展,非人类灵长类动物的突触密度增加与人类胎儿可控性降低相关.
- 母亲的可控性呈现出反向的U形轨迹,在36周左右达到顶峰,与胎儿的可控性相反相关.
结论:
- 胎儿大脑的可控性遵循非线性发育轨迹,与突触发育密切相关.
- 这种轨迹与怀孕期间母亲大脑可控性变化同步,表明了协调的发育过程.
- 了解这些动态,可以了解神经发育轨迹和早产的潜在影响.
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