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Updated: May 6, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

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基于TDP-43功能丧失分子标记物的分子和临床ALS亚组的鉴定,来自基于人群的患者衍生的iPS运动神经元

Trinity Cheng, Shaili Tripathi, Yike Guo

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    概括

    研究人员使用RNA分析确定了四种不同的肌缩性侧面硬化症 (ALS) 分子类型. 这些亚型与临床结果相关,为个性化ALS治疗铺平了道路.

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    Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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