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Updated: Jan 18, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
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Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss

Published on: April 24, 2020

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慢性ER压力破坏了角质内皮细胞中线粒体相关的ER膜完整性

Stephanie Lee, Stefan Y Kim, H Orhan Akman

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    概括

    福克斯 (Fuchs) 是一个

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    Determining the Toxicity of UV Radiation and Chemicals on Primary and Immortalized Human Corneal Epithelial Cells09:31

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    相关概念视频

    Role of ER in the Secretory Pathway01:17

    Role of ER in the Secretory Pathway

    Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
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    Export of Misfolded Proteins out of the ER01:32

    Export of Misfolded Proteins out of the ER

    After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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    The Endoplasmic Reticulum01:43

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    The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
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