相关实验视频

Updated: Jan 18, 2026

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia
06:43

In Vivo Proximity Biotinylation for Protein Interaction Studies in Paramecium tetraurelia

Published on: September 12, 2025

1.1K

在Oxytricha中,PIWI蛋白依赖的DNA N6-腺因甲基化通路保护基因组序列免受删除

Margarita T Angelova, Yi Feng, Danylo J Villano

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    概括

    由MTA1催化并由Otiwi1指导的DNAN6-氨酸甲基化,保护DNA区域在Oxytricha发育过程中免受删除. 这种表观遗传标记通过编程的DNA重组来确保基因组的稳定性.

    更多相关视频

    Immunostaining for DNA Modifications: Computational Analysis of Confocal Images09:42

    Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

    Published on: September 7, 2017

    10.2K
    DNAzyme-dependent Analysis of rRNA 2’-O-Methylation09:12

    DNAzyme-dependent Analysis of rRNA 2’-O-Methylation

    Published on: September 16, 2019

    8.8K

    相关概念视频

    piRNA - Piwi-interacting RNAs02:57

    piRNA - Piwi-interacting RNAs

    PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
    7.5K
    Mismatch Repair01:20

    Mismatch Repair

    Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
    The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
    The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
    6.3K
    Mismatch Repair01:36

    Mismatch Repair

    Overview
    43.5K
    Epigenetic Regulation01:46

    Epigenetic Regulation

    Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
    33.5K
    Epigenetic Regulation01:37

    Epigenetic Regulation

    Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
    X-chromosome...
    3.7K
    DNA Damage can Stall the Cell Cycle02:36

    DNA Damage can Stall the Cell Cycle

    In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
    10.0K