心血管健康和遗传风险的左心室质量与左心室结构,功能和事件心血管结果的关联
medRxiv : the preprint server for health sciences
|January 16, 2026
概括
糟糕的心血管健康与高遗传风险相结合,显著增加了不良心脏重塑和心血管疾病 (CVD) 的风险. 这凸显了生活方式和遗传学在心血管疾病发展中的重要性.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 心血管健康 (CVH) 和对不良左心室 (LV) 重塑的遗传易感性与心血管疾病 (CVD) 独立相关.
- 关于CVH和遗传倾向对心血管疾病风险和LV重塑的综合影响仍然不完全理解.
研究的目的:
- 研究可修改的心血管健康因素和遗传风险对LV结构,功能和发生心血管疾病的协同效应.
- 评估生活必需8 (LE8) 评分和LV质量指数 (LVMI) 的多基因风险评分 (PRS) 的组合如何与不良心血管结果有关.
主要方法:
- 利用来自后代和第三代队伍的弗雷明汉心脏研究数据.
- 使用美国心脏协会的生命必需8 (LE8) 评分评估可修改的风险因素,并计算了LV质量指数 (LVMI) 的多基因风险评分 (PRS).
- 创建了基于LE8和PRS三位体的9个风险组,并使用回归模型分析了它们与LVMI,LVEF,E/e'比率和事件CVD的关联.
主要成果:
- 参与者心血管健康处于中等水平 (LE8平均得分为70) 和正常的基线 LV 结构和功能.
- 在19年中,低LE8分数和高PRS的个体表现出明显更高的LVMI和E/e'比率.
- 与最佳风险组相比,低LE8高PRS组显示发生心血管疾病和冠心病 (CHD) 的风险增加了三倍以上.
结论:
- 更糟糕的心血管健康 (较低的LE8分数) 与高遗传风险 (高PRS) 协同作用,从而增加不利的LV结构和功能的风险.
- 基于生活方式的CVH和遗传倾向的联合评估对于预测和潜在地减轻心血管疾病发展至关重要.
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