相关实验视频

Updated: Jan 18, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

在头部和部癌症放射治疗期间医疗量身定制的食:试点随机对照试验

Hania M Taha^1,2,3, Hannah D Holscher^1,4, Fadi Atrash²

¹Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Nutrition and cancer

|January 16, 2026

概括

使用碳水化合物限制,高脂肪饮食的医疗定制餐 (MTM) 对接受放射治疗的头癌患者来说是可行的和可以接受的. 这种方法可能有助于保存肌肉,并减少治疗期间的脂肪损失.

科学领域:

在瘤学瘤学.
营养科学营养科学
临床试验临床试验

背景情况:

头癌 (HNC) 患者经常经历体重和肌肉损失.
宏观营养素组成在管理HNC相关缓解症中的作用还未得到充分研究.
放射治疗 (RT) 加剧了HNC患者的营养挑战.

研究的目的:

评估与标准饮食 (SD) 相比,家庭送餐,医疗定制餐 (MTM) 的可行性和可接受性,其中包括碳水化合物限制,高脂肪 (CRHF) 饮食.
在接受RT的新诊断的HNC患者中评估这些饮食.
通过探索体重和身体组成的变化,为未来的试验设计提供信息.

主要方法:

试点随机对照试验与13名HNC患者随机分配到CRHF (n=6) 或SD (n=7) 组.
在RT前两周和RT期间,每天服用同热量MTM.
通过招聘,保留,坚持和接受度评估可行性;探索性身体组成分析.

主要成果:

招聘和保留率分别为65%和69%.
报告的MTM的高度坚持 (92%CRHF,96%SD) 和参与者的满意度.
CRHF组显示了较大的肌肉保存和脂肪损失的初步模式.
对任何一种饮食的更高坚持与在RT期间减肥较少相关.

结论:

自宅配送的MTM,包括CRHF配方,在RT期间对HNC患者来说是可行的和可以接受的.
"食物是药物"的方法显示出对HNC的营养支持有希望.
需要在更大的试验中进行进一步的研究,以确认在控制体重和身体组成方面的有效性.

更多相关视频

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

相关概念视频

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...