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相关概念视频

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

715
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
715
Drug Delivery: Overview01:16

Drug Delivery: Overview

730
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
730
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

2.0K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.0K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

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In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
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相关实验视频

Updated: Jan 18, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

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工程交付平台用于控制的氧化释放.

Sang-Hun Choi1, Chae Yeon Han1, Kyeong Jin Cho1

  • 1School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea. jihoonkim@cau.ac.kr.

Biomaterials science
|January 16, 2026
PubMed
概括
此摘要是机器生成的。

由于稳定性和控制性差,氧化 (NO) 的输送面临着挑战. 新的NO捐赠化合物和先进的输送平台,如纳米颗粒和水凝,为精确的向疗法提供了潜力.

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Designing Porous Silicon Films as Carriers of Nerve Growth Factor
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Designing Porous Silicon Films as Carriers of Nerve Growth Factor

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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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相关实验视频

Last Updated: Jan 18, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
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Designing Porous Silicon Films as Carriers of Nerve Growth Factor
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Designing Porous Silicon Films as Carriers of Nerve Growth Factor

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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 氧化 (NO) 是一种关键的信号分子,在各种领域具有治疗潜力.
  • 由于溶解性差,降解速度快,以及缺乏可控释放,NO的临床使用受到限制.
  • 现有的NO捐赠者具有明显的优势和局限性.

研究的目的:

  • 审查氧化物 (NO) 供体化学和输送系统的最新进展.
  • 将NO的捐赠者分为不稳定和稳定的类别.
  • 突出NO的捐赠化学与材料设计的整合,以提高治疗效果.

主要方法:

  • 将NO捐赠体分为不稳定的 (例如,N-diazeniumdiolates,S-nitrosothiols,SIN-1) 和稳定的 (例如,O2受保护的diazeniumdiolates,受保护的SIN-1,酸衍生物,BNN6) 类型.
  • 复习先进的交付平台,包括纳米粒子,水凝,凝,脂质体和无机材料.
  • 分析刺激触发的NO释放机制和组织特定的向策略.

主要成果:

  • 开发具有不同释放特征的多种NO捐赠体.
  • 交付平台的工程,使精确的,刺激触发的NO释放.
  • 证明了NO输送系统的稳定性和组织特异性向的改进.

结论:

  • 将NO的捐赠化学与材料科学相结合,为基于NO的可控疗法提供了巨大的潜力.
  • 先进的输送平台可以克服NO的物理化学限制.
  • 需要进一步的研究来将这些NO输送系统转化为临床应用.