艾滋病毒感染者的认知和脑成像的纵向变化
James Kennedy1, Sarah A Cooley1, June Roman Fox1
1Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
The Journal of infectious diseases
|January 16, 2026
概括
与没有艾滋病毒的人相比,艾滋病毒感染者 (PWH) 具有不可检测的病毒载量没有加速的认知或大脑衰老. 然而,具有可检测病毒的PWH面临更高的认知衰退和大脑变化的风险.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 艾滋病毒感染者的老龄化人口 (PWH) 需要了解艾滋病毒对老龄化和大脑健康的影响.
- 老龄化中的认知障碍PWH是一个越来越令人担忧的问题,受艾滋病毒,老龄化和大脑完整性的影响.
研究的目的:
- 分析衰老,艾滋病毒血清状况和病毒载荷对认知和大脑体积的影响.
- 为了比较无艾滋病毒 (PWoH),无可检测病毒 (PWHU) 的PWH和可检测病毒 (PHWD) 的PWH的人的认知表现和脑结构随时间变化.
主要方法:
- 使用了来自259个PWoH,264个PWHU和84个PHWD (共841个会议) 的横截面和纵向数据.
- 通过复合分数 (NPZ4) 和测量区域大脑体积来评估认知功能.
- 采用了通用添加混合模型来检查与年龄相关的认知和大脑体积的变化和相互作用.
主要成果:
- 没有检测到病毒 (PWHU) 的PWH和PWoH表现出类似的认知衰老轨迹;PHWD表现出更的认知衰退.
- 两个PWH组的区域大脑体积都比PWoH小,与年龄相关的体积损失斜率相似,除了晶状区域.
- 在PHWD中,较小的大脑体积和晚年显著相互作用,预测了更大的认知衰退.
结论:
- 与PWoH相比,PWH中的病毒抑制可以防止加速的认知衰退和大脑体积损失.
- 患有PHWD的人面临加速认知衰退的风险增加,这凸显了病毒载荷管理在老化PWH中的重要性.
- 实现病毒抑制可以缓解PWH中加速的大脑衰老.
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