Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Relative Motion Analysis using Rotating Axes-Problem Solving01:29

Relative Motion Analysis using Rotating Axes-Problem Solving

Consider a crane whose telescopic boom rotates with an angular velocity of 0.04 rad/s and angular acceleration of 0.02 rad/s2. Along with the rotation, the boom also extends linearly with a uniform speed of 5 m/s. The extension of the boom is measured at point D, which is measured with respect to the fixed point C on the other end of the boom. For the given instant, the distance between points C and D is 60 meters.
Here, in order to determine the magnitude of velocity and acceleration for point...
Modeling and Similitude01:12

Modeling and Similitude

Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

Molecular psychiatry·2026
Same author

Lower Muscarinic M1 Receptor Availability in Schizophrenia: In Vivo PET Evidence.

Biological psychiatry·2026
Same author

Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson's disease severity.

NPJ Parkinson's disease·2026
Same author

Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [<sup>11</sup>C]PHNO PET study.

Psychiatry research·2026
Same author

Optimization of brain PET markerless head motion correction in a large human cohort.

EJNMMI physics·2026
Same author

Lower synaptic density in mood circuitry underlies depression in Parkinson's disease.

Brain communications·2026
Same journal

EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Mechanical Compaction Alters Microstructural and Magnetic Resonance Imaging Properties of Acute Ischemic Stroke Clots.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Multi-modal Magnetic Resonance Imaging to Assess Cerebrovascular Function in Patients with Atrial Fibrillation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Trifluoperazine reduces infarct size, restores neurovascular coupling and improves early outcomes in experimental acute ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Advances in artificial intelligence for neuroimaging.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
查看所有相关文章

相关实验视频

Updated: Jun 13, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.8K

"基于伪参考的输入函数形状" (pRef-IFS):对于PET动态建模的真实图像衍生的输入函数.

Tommaso Volpi1,2, Mika Naganawa1,2, Richard E Carson1,2

  • 1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
|January 16, 2026
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的非侵入性方法,即基于伪参考的输入函数形状 (pRef-IFS),用于估计PET成像的等离子体输入函数. pRef-IFS显示出与单组织动力学准确量化的承诺,即使是不完美的参考区域.

关键词:
用代谢物纠正的血输入函数输入函数.清除率常数 k2′一个组织隔间模型.伪参考地区伪参考地区简化的参考组织模型.

更多相关视频

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories
07:52

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Published on: July 10, 2019

15.0K
Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing
06:25

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Published on: February 23, 2024

1.1K

相关实验视频

Last Updated: Jun 13, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.8K
Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories
07:52

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Published on: July 10, 2019

15.0K
Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing
06:25

Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing

Published on: February 23, 2024

1.1K

科学领域:

  • 核医学就是核医学.
  • 放射化学 放射化学是指辐射化学.
  • 药理动力学 药理动力学

背景情况:

  • 在正子发射断层扫描 (PET) 中的绝对量化依赖于精确的代谢物校正的血输入函数 (CP).
  • 非侵入性地获得CP具有挑战性,特别是当理想的参考区域无法用于PET成像时.
  • 现有的方法往往需要侵入性程序或理想的参考区域,限制广泛的适用性.

研究的目的:

  • 引入和评估一种新的非侵入性方法,即基于伪参考的输入函数形状 (pRef-IFS),用于估计PET中的CP.
  • 在不同的动力模型和参考区域属性下评估pRef-IFS的性能.
  • 为了确定不准确的动力参数估计对pRef-IFS.准确性的影响.

主要方法:

  • pRef-IFS从伪参考区域 (pRef) 估计CP形状,使用一个单组织 (1T) 隔间模型.
  • 使用简化参考组织模型 (SRTM) 估计或假设pRef清除率 (k'2).
  • 未缩放的CP形状随后使用早期图像衍生血液时间活性曲线 (ID-BTAC) 进行缩放.

主要成果:

  • 在1T动力学下,SRTM估计的k'2是无偏的,而pRef-IFS在人类数据中产生了小的分布体积 (VT) 偏差 (例如,C-LSN3172176: -2±5%到11±8%).
  • pRef-IFS的性能降低了两种组织动力学,特别是像F-FPEB这样的标记物,尽管一些标记物 (F-ASEM) 显示出最小的偏差 (-4±10%).
  • pRef-IFS的准确性取决于遵守1T运动假设和ID-BTAC缩放的质量.

结论:

  • pRef-IFS为PET绝对量化提供了一个有希望的完全非侵入性方法,当放射性追踪剂表现出单组织动力学时.
  • 该方法即使在伪参考区域中具有适度的特定结合,也具有稳定性,前提是实现了准确的ID-BTAC缩放.
  • 对于具有复杂 (双组织) 动力学或当参考区域假设明显违反时的标记物需要进一步验证.