[替代性毒素作为健康威胁:细胞毒性作用]
A D Konev1, I B Sedova1, V A Tutelyan1,2
1Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Voprosy pitaniia
|January 16, 2026
概括
在食物中发现的真菌代谢产物Alternaria毒素对健康构成风险. 替代 (AOH) 已被证实是危险的,而对于其他毒素,如AME和TeA,则需要更多的数据.
科学领域:
- 食品科学 食品科学 食品科学
- 毒理学 毒理学 毒理学
- 菌类学 菌类学是指菌类学.
背景情况:
- 替代菌毒素是越来越多地在食品中检测到的真菌代谢物.
- 它们对健康的潜在危害尚未得到充分了解,缺乏监管限制.
- 许多Alternaria毒素在毒理学特征方面仍未得到研究.
研究的目的:
- 审查和总结各种Alternaria毒素对细胞毒性作用的研究.
- 分析关于Alternaria毒素毒性的体外和体内实验数据.
- 识别有关这些真菌代谢产物对健康的风险的知识差距.
主要方法:
- 在PubMed,谷歌学者和Cyberleninka中进行文献搜索.
- 关键词包括:阿尔特纳里亚,阿尔特纳里亚毒素,细胞毒性,氧化应激,毒性.
- 对调查细胞毒性影响,DNA损伤和氧化应激的研究进行分析.
主要成果:
- 替代醇 (AOH) 呈现剂量依赖的细胞毒性和DNA损伤潜力.
- 替代醇单甲基乙烯 (AME) 和十亚酸 (TeA) 也表现出细胞毒性作用,并诱导氧化应激.
- 烯基 (ATX II,ATX III,STTX III,ALTP) 显示出由于环氧基的高细胞毒性.
- 泰托克辛 (TEN) 和老烯 (ALT) 显示出有限或矛盾的细胞毒性作用.
- 混合Alternaria毒素可以具有添加或协同作用.
结论:
- 足够的证据证实了Alternariol (AOH) 作为一种健康危害.
- 需要对AOH和AME进行进一步的体内遗传毒性数据,特别是对于胃肠道.
- 需要对其他Alternaria毒素的毒性和氧化应激影响进行更多的研究,特别是烯.
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