来自Ganoderma multipileum的果实体中的兰诺斯坦三类化合物及其抗炎活性
Mei-Juan Li1, Qing-Yun Ma2, Li Yang2
1College of Forestry, Southwest Forestry University, Kunming, Yunnan, China.
Natural product research
|January 16, 2026
概括
鉴定了来自Ganoderma multipileum的一种新的lanostane三烯酸. 化合物4和5通过抑制细胞中氧化 (NO) 生成,显示出显著的抗炎活性.
科学领域:
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 甘菌物种是已知的生物活性化合物的来源.
- 三聚类,特别是兰诺斯坦类型,表现出不同的药理性质.
- 炎症是一种复杂的生物反应,与各种疾病有关.
研究的目的:
- 从Ganoderma multipileum中分离和描述新的化合物.
- 评估隔离化合物的抗炎潜力.
- 为了阐明一种新的lanostane类型三基的结构.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过核磁共振 (NMR) 谱学和高分辨率电喷射电离化质谱学 (HRESIMS) 进行结构阐明.
- 计算分析包括NMR化学转移预测和DP4+分析.
- 在体外抗炎测定使用脂聚糖 (LPS) 刺激的RAW264.7细胞来测量氧化 (NO) 生产.
主要成果:
- 一种新型的lanostane类型的三基 (25S) - 3β,15β-二基-7,11,23-trioxo-lanost-8,17(20) -dien-26-oic酸 (1) 被分离并进行了结构性特征.
- 从同一个提取物中也确定了15种已知的化合物 (2-16).
- 化合物4和5在LPS刺激的RAW264.7细胞中显著抑制了NO生成,IC50值分别为12.89±0.50μM和27.55±2.95μM.
- 化合物4和5的抗炎功效与奎尔丁的抗炎功效相当 (IC50:11.80±1.75μM).
结论:
- 多 (Ganoderma multipileum) 是结构多样化的三类植物的丰富来源.
- 新发现的化合物和几种已知的化合物具有抗炎性质.
- 化合物4和5是作为抗炎剂进一步研究的有希望的候选物.
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