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在美国成年人中,牙线使用频率与口腔微生物组之间的关联
Zhijing Xu1, Jinyu Hu1, Huabin Luo2
1New York University Rory Meyers College of Nursing, New York, NY, USA.
Annals of medicine
|January 16, 2026
概括
每天使用牙线与口腔微生物群的差异较小有关,这可能表明微生物群体更健康. 这项以人口为基础的研究揭示了使用牙线的频率和微生物丰富性降低之间的剂量反应关系.
科学领域:
- 微生物组研究的研究.
- 口腔健康研究 口腔健康研究
- 公共卫生 公共卫生
背景情况:
- 口腔微生物组在维持健康方面发挥着至关重要的作用.
- 有限的基于人口的数据存在于牙线习惯和口腔微生物群落之间的关系.
- 这项研究通过检查美国成年人来解决这个差距.
研究的目的:
- 调查自我报告的牙线使用频率与口腔微生物群多样性之间的关联.
- 分析基于人口的关于使用牙线对微生物群落影响的证据.
- 在全国代表性样本中探索潜在的剂量反应关系.
主要方法:
- 从NHANES 2009-2012对4772名美国成年人 (30-69岁) 的横截面分析.
- 牙线使用频率的分类:非使用者,一些使用牙线 (每周1-6天) 和每日使用者 (每周7天).
- 通过16SrRNA测序进行口腔微生物群的分析;多样性分析 (α-和β-多样性);调整后回归模型.
主要成果:
- 发现了一种剂量与反应的关系:增加使用牙线的频率与减少微生物丰富性和植物遗传多样性相关.
- 与非使用者相比,每天使用牙线与较低的财富 (观察到的ASV) 和家族遗传多样性 (Faith的PD) 有显著的关联.
- 虽然β-多样性在不同组之间存在差异,但效应大小小;相反的关联在年轻,低收入的成年人中更为明显.
结论:
- 频繁使用牙线与口腔微生物丰富性和植物遗传多样性降低有关.
- 这种转变可能表明,我们正朝着更健康的口腔微生物群落迈进.
- 这些发现突出了口腔卫生实践和口腔微生物群之间的复杂相互作用.
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