牛奶口服免疫疗法在现实生活中:长达15年的随访研究
 Gaspar1, S Piedade1, C Monteiro-Marques1
1Department of Immunoallergy, Hospital da Luz Lisboa, Lisbon, Portugal.
European annals of allergy and clinical immunology
|January 16, 2026
概括
牛的长期口服免疫疗法 (OIT)
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 牛奶 (CM) 过敏严重影响儿童的生活质量.
- 口服免疫疗法 (OIT) 是有前途的,但需要大量的长期数据.
- 关于OIT维护阶段的现实证据有限.
研究的目的:
- 评估牛奶口服免疫疗法 (CM-OIT) 的长期疗效和安全性.
- 在现实环境中评估CM-OIT维护阶段的结果.
- 在长期OIT随访期间分析临床和实验室标志物.
主要方法:
- 对患有严重IgE介导的CM过敏的儿童进行前性研究,接受CM-OIT.
- 长期随访长达15年,评估完全脱敏 (200毫升每日CM摄入量).
- 在OIT之前和之后的临床和实验室表征.
主要成果:
- 94%的患者实现了完全的脱敏,使得他们可以自由饮食.
- 79%的患者在维护期间出现过敏反应,其中33%的患者有过敏反应.
- 特定IgE和皮肤刺伤测试 (SPT) 水平显著下降;61%的SPT呈阴性.
结论:
- CM-OIT证明了长期的疗效和安全性,持续效果长达15年.
- 高成功率允许不受限制的饮食,但在维持期间,过敏反应的风险仍然存在.
- 专家监督和积极的家庭对于成功的长期CM-OIT管理至关重要.
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