人口普查通道水平的持续贫困和肝癌存活率:基于人口的研究
1Columbia University United States.
概括
生活在持续的贫困中与更糟糕的肝癌存活率有关. 这凸显了在经济不利的社区进行有针对性的干预的必要性,以减少癌症差异.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 健康的社会经济决定因素
背景情况:
- 在美国,肝癌发病率和死亡率正在增加,种族和社会经济差异显著.
- 持续的贫困,定义为社区≥20%的联邦贫困线居民≥30年,是癌症生存的一个研究不足的因素.
- 这项研究调查了人口普查通道层面持续贫困与肝癌生存结果之间的联系.
研究的目的:
- 检查人口普查通道水平持续贫困和肝癌存活率之间的关系.
- 确定持续的贫困是否影响癌症特定和整体死亡率.
- 确定改变这种关联的人口和临床因素.
主要方法:
- 从SEER 17注册表分析了2006-2019年间诊断的73,695名成年肝癌患者.
- 根据患者在诊断时的居住地,分配持续的贫困状态.
- 使用卡普兰-梅尔和考克斯模型进行生存分析,对共变量进行调整并评估效应修改.
主要成果:
- 11%的患者居住在持续的贫困地区.
- 持续贫困地区 (16个月) 与非持续贫困地区 (22个月) 的中位癌症特异性存活率明显较低.
- 持续的贫困与癌症特定死亡率增加9%和全因死亡率增加11%有关,特别是在年轻患者 (<65岁) 和局部疾病患者中.
结论:
- 居住在持续的贫困人口普查区中独立地与较差的肝癌存活率有关.
- 解决社会经济劣势的干预和政策对于减轻肝癌生存率差异至关重要.
- 这些发现强调了在癌症护理和政策中考虑社会经济背景的重要性.
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