低剂量的埃多克萨班和非膜心房动患者在现实世界中的临床结果:一项回顾性队列研究
Wenjun Yang1, Jieyi Gao2, Jie Chen1
1Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
概括
在亚洲患有非膜性心房动 (AF) 的患者中,低剂量的埃多克萨班与推剂量相比,显示出类似的有效性和较大的出血风险. 然而,低剂量可能会减少临床相关的非重大出血事件.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在亚洲临床实践中,低剂量埃多克萨班在非膜性心房动 (AF) 的治疗中很常见.
- 在AF患者中服用低剂量埃多克萨班的现实结果尚未得到充分证实.
- 本研究涉及中国AF队列中低剂量的edoxaban的有效性和安全性.
研究的目的:
- 为了评估低剂量埃多克萨班的实际有效性和安全性,与非膜AF患者的推剂量相比.
- 为了在剂量组之间比较缺血性中风 (IS) 或全身血栓塞 (SE) 风险.
- 评估重大出血,临床相关的非重大出血 (CRNM) 和全因死亡率.
主要方法:
- 在中国一家三级医院进行的回顾性队列研究.
- 根据国际标准,将患者分为推和低剂量埃多克萨班组.
- 使用治疗权重的逆概率 (IPTW) 进行比较分析.
主要成果:
- 在616名非膜性AF患者中的31.5%,接受过低剂量的edoxaban.
- 两组之间在IS/SE,重大出血或全因死亡率上没有显著差异.
- 低剂量的埃多克萨班与CRNM出血显著减少有关 (HR 0.47,95%CI 0.23-0.95).
结论:
- 在中国近三分之一的非膜性肌痛前列腺炎患者中,服用过少剂量的埃多克萨班显示出相似的IS/SE和重大出血风险.
- 在低剂量的edoxaban.com时,观察到CRNM出血的潜在较低发生率.
- 这些发现是初步的,需要在更大的前性研究中进行验证.
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