Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Human Genetics01:28

Human Genetics

1.5K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Design and development of a convolutional neural network based on human cognitive attention mechanism for automatic classification of leukemia.

PloS one·2026
Same author

An evolutionary machine learning algorithm for cardiovascular disease risk prediction.

PloS one·2022
Same author

Prevention of landfill pollution by multicriteria spatial decision support systems (MC-SDSS): development, implementation, and case study.

Environmental science and pollution research international·2018
查看所有相关文章

相关实验视频

Updated: Jan 18, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

通过使用遗传算法和SHAP值的可解释CNN来预测阿尔茨海默病.

Mohammad Zahedipour1, Mohammad Saniee Abadeh1,2, Shakila Shojaei1,3

  • 1Faculty of Electrical and Computer Engineering, Tarbiat Modares University, Tehran, Iran.

PloS one
|January 16, 2026
PubMed
概括

这项研究介绍了GASHAP,一种结合遗传算法和SHAP的新可解释的人工智能技术,以提高3D-CNN模型的透明度,用于使用MRI扫描来诊断阿尔茨海默病.

科学领域:

  • 人工智能的人工智能
  • 医学成像分析 医学成像分析
  • 神经科学是一个神经科学.

背景情况:

  • 像3D-CNNs这样的深度学习模型在图像分类方面表现出色,但缺乏透明度.
  • 解读黑子模型在医疗保健中具有挑战性,特别是在诊断像阿尔茨海默氏症这样的疾病时.
  • 可解释的人工智能 (XAI) 技术旨在提高模型的解释性.

研究的目的:

  • 引入GASHAP,一种新的XAI技术,将遗传算法 (GA) 与SHAP集成,以提高3D-CNN的解释性.
  • 为了提高3D-CNN模型的透明度,用于MRI扫描中对阿尔茨海默病的分类.
  • 在解剖学上定义的大脑区域的水平上提供诊断见解,超越voxel级别的分析.

主要方法:

  • 在MRI脑部扫描中实施了3D-CNN来分类阿尔茨海默病.
  • 应用了GASHAP技术,将GA和SHAP结合起来,以确定重要的大脑区域.
  • 产生了明确的脑罩,突出了阿尔茨海默病诊断的关键区域.

主要成果:

  • 从MRI扫描中开发了一个3D-CNN模型来对阿尔茨海默病的分类.
  • 成功应用GASHAP以提高模型的透明度和可解释性.

更多相关视频

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.3K

相关实验视频

Last Updated: Jan 18, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.3K
  • 制造了一个脑罩,精确定位了阿尔茨海默氏症诊断的关键解剖区域.

    • 结论:

    • 在医学成像中,GASHAP为3D-CNNs提供了更好的解释能力.
    • 该技术有助于识别阿尔茨海默病诊断的关键大脑区域.
    • 这种方法提高了AI在神经退行性疾病检测中的临床实用性.