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Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...

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含有药物的纳米粒子用于关节内注射.

Piaopiao Pan^1,2, Konstantina Simou³, Yanting Ouyang⁴

¹School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, PR China.

|January 16, 2026

概括

新型药物装载纳米粒子 (NP) 已开发用于关节内注射 (IAI) 治疗早期关节炎 (OA). 这些NP显著改善了关节滑,并证明了持续的药物释放和出色的生物相容性.

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科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
类风湿病学类风湿病学

背景情况:

骨关节炎 (OA) 是一种退行性关节疾病,需要有效的治疗策略.
关节内注射 (IAI) 为关节疾病提供局部药物输送.
目前的IAI配方可能在持续释放和滑增强方面存在局限性.

研究的目的:

开发和描述药物载荷纳米粒子 (NP) 作为早期OA的IAI模型配方.
评估开发的NP在人工关节表面上的滑性能.
评估NP配方的药物释放特征和生物相容性.

主要方法:

使用混合同质化和溶剂蒸发技术制备了装载着塞莱科克西布的纳米粒子.
纳米粒子的表征包括水力动力直径和泽塔电位测量.
使用摩擦测试,石英晶微平衡 (QCM) 和原子力显微镜 (AFM) 评估了滑性.
评估了药物释放动力学和状细胞细胞毒性.

主要成果:

纳米粒子呈现出大约200nm的水力动力直径和负泽塔电位 (~-40mV).
这些NP显著提高了模型关节表面 (不钢和弹性体) 之间的滑.
对NP的表面吸附被确定为改善滑的关键因素.
观察到持续释放塞莱科克西布超过一周,在状细胞测定中具有很好的生物相容性.

结论:

含有药物的纳米颗粒显示出作为一种先进的IAI治疗骨关节炎的配方的希望.
与免费赛莱科克西布相比,NP提供了更好的滑和持续的药物输送.
该配方显示出良好的生物相容性,支持其潜在的治疗应用.