针对短段赫施普朗格病的一阶段新生儿治疗方法的安全性和可行性
Quynh Anh Tran1, Hien Duy Pham1, Dung Boi Ly2
1Department of Surgery, The National Hospital of Pediatrics, Dong Da, Hanoi, Vietnam.
PloS one
|January 16, 2026
概括
对于新生儿的希尔施普朗格病 (HD) 的最小侵入性手术,包括SILEP,CLEP和TERPT,显示了可比的长期肠道功能. SILEP和TERPT提供更短的操作时间,SILEP趋向于更好的化品结果.
科学领域:
- 儿科手术 儿科手术
- 最少侵入性的手术
- 新生儿护理 新生儿护理
背景情况:
- 针对新生儿的赫施普朗格病 (HD) 的早期确定的手术旨在减少发病率并改善长期的肠功能.
- 在新生儿中对短段直交形HD的微创方法的比较数据是有限的.
研究的目的:
- 为了比较单次切口腹腔镜辅助内肠直肠拉透 (SILEP),常规腹腔镜辅助内肠直肠拉透 (CLEP) 和完整的透过内肠直肠拉透 (TERPT) 的结果,用于新生儿的直腰肌状HD.
- 评估长期肠道功能,手术参数,并发症和化品结果.
主要方法:
- 对55名新生儿进行了回顾性队列研究,这些新生儿在28天前接受了直交肌性HD的一阶段确定性手术.
- 主要结局:在至少4年后进行腹肠功能评分 (Rintala Bowel Function Score,BFS).
- 二次结果:手术时间,Clavien Dindo并发症,以及曼彻斯特痕量表 (MSS) 的化品结果.
主要成果:
- 所有手术都是成功的,没有死亡率或严重并发症 (Clavien Dindo等级IV-V).
- 与CLEP (70.2分钟) 相比,SILEP (53.8分钟) 和TERPT (52.1分钟) 的操作时间更短.
- 长期肠功能 (BFS) 和化品评分 (MSS) 在两组之间没有显著差异,尽管SILEP的化品趋势比CLEP更好.
结论:
- SILEP,CLEP和TERPT是可行的一个阶段的手术选择,用于患有直交肌性HD的新生儿.
- 这些方法表明可比的长期肠道功能和较低的重大并发症率.
- 技术选择应根据操作需求和外科专业知识进行个性化选择.
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