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Updated: Jan 18, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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NTCP的结构映射区分其作为乙型肝炎病毒受体和胆酸载体的双重功能

Kayo Matsuzawa1,2, Toru Ekimoto3, Chisa Kobayashi1

  • 1Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.

PLoS pathogens
|January 16, 2026
PubMed
概括

研究人员绘制了 taurolate 同载聚 (NTCP) 蛋白的关键氨基酸残留物. 这揭示了NTCP如何作为胆酸载体和肝炎病毒受体发挥作用,指导新的抗病毒药物设计.

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