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Updated: Jan 18, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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全基因组查确定了BAP1作为一种合成致死性标,具有CDK4/6抑制剂

Mei Feng1, Hong Liu2,3, Lu Zheng4

  • 1International Cancer Institute and Translational Cancer Research Center, Peking University First Hospital, Beijing, China.

Science advances
|January 16, 2026
PubMed
概括

癌细胞通过涉及BAP1.1的表观遗传途径对CDK4/6抑制剂产生抗性. 向BAP1可以提高肝胆癌的药物疗效,为抗适应性耐药性提供新的策略.

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