非综合症多焦点低度瘤性脏瘤,包括微型瘤,在末期脏病脏与同步的非TSC脏细胞新生体
Qi Cai1, Liwei Jia1, Jyoti Balani1
1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
International journal of surgical pathology
|January 16, 2026
概括
多焦点低度瘤瘤 (LOTs),包括小瘤,可以发生在没有结核硬化综合体 (TSC) 的末期病 (ESRD) 患者. 这些发现表明,在ESRD患者中,LOT可能独立于TSC出现,需要更广泛的认可.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 低度瘤细胞瘤 (LOT) 是一种惰性瘤,通常与TSC/MTOR途径突变有关.
- 在正常功能患者中,LOT通常呈现为零星,单一的瘤.
- 多焦点LOT很少见,通常与结核性硬化综合体 (TSC) 相关.
研究的目的:
- 在没有临床TSC的慢性病 (CKD) 或末期病 (ESRD) 患者中描述多焦点LOT,包括微瘤.
- 在ESRD的背景下,调查多焦点LOT与其他瘤的同时发生.
- 突出LOT在ESRD中独立于遗传TSC出现的潜力.
主要方法:
- 四名患有多焦点LOT和CKD/ESRD的患者的病例系列.
- 细致的瘤病理检查,细致的瘤病理检查.
- 临床数据审查,重点关注TSC特征和共存的细胞瘤.
主要成果:
- 在CKD/ESRD的背景下,四名患者呈现出多焦点LOT (包括微瘤),没有临床TSC.
- 一名患者有双边多焦点LOT与获得的囊性疾病相关细胞癌 (ACD-RCC).
- 两名患者同时患有清晰细胞状脏细胞瘤 (CCPRCT),其中一名患有多焦点LOT;第四名患有CCPRT,ACD-RCC和多焦点LOT.
结论:
- 多焦点LOT,包括微瘤,可以发生在ESRD患者独立于遗传TSC.
- 观察到LOT与其他ESRD相关瘤 (ACD-RCC,CCPRCT) 的同时发生.
- 在ESRD的背景下,对LOT的更广泛的认可是合理的.
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