POSTN+与癌症相关的纤维细胞通过血管生成和免疫调节促进膀癌症的进展:基于单细胞转录组学的分析
Qun Zhang1, Bo Zhang2, Jirui Niu3
1Department of Quality Control Office, Heilongjiang Provincial Hospital, No. 82, Zhongshan Road, Xiangfang District, Harbin City, Heilongjiang Province, 150036, China.
Integrative biology : quantitative biosciences from nano to macro
|January 16, 2026
概括
与癌症相关的纤维细胞 (CAFs) 分泌皮质素 (POSTN) 通过增加血管生成,迁移和免疫抑制来促进膀癌 (BCa) 的生长. POSTN表达表明BCa患者的预后不佳.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 膀癌 (BCa) 的进展受到瘤微环境的影响,特别是与癌症相关的纤维细胞 (CAF).
- 一种由CAF分泌的蛋白质环素 (POSTN) 涉及瘤恶性,但其在BCa中的确切作用尚未完全理解.
研究的目的:
- 研究POSTN表达CAFs (POSTN+CAFs) 在膀癌进展中的作用.
- 阐明 POSTN+ CAFs 影响瘤微环境和癌细胞行为的机制.
主要方法:
- 来自BCa和对照样本的单细胞和批量转录组数据的二次分析.
- 使用差异性基因表达,通路分析和细胞-细胞通信工具,对POSTN+ CAF及其与单细胞的通信进行表征.
- 在共同培养系统中使用TCGA数据和功能分析验证POSTN的预后意义.
主要成果:
- POSTN+ CAFs在BCa中显著丰富,并促进了血管生成,迁移和入侵.
- 通过IL1B/IL1R1轴,CAF和单细胞之间的增强通信有助于形成免疫抑制的微环境.
- POSTN上调与BCa患者的预后不佳相关,而POSTN倒置减少了CAF介导的癌细胞入侵.
结论:
- POSTN+ CAFs是膀癌进展的关键驱动因素.
- 在BCa微环境中,POSTN+ CAF增强了血管生成,迁移和免疫抑制.
- IL1B/IL1R1轴在中介POSTN+ CAFs对瘤微环境的影响方面发挥着作用.
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