通过多层增长战略,在兰化物上升转换纳米颗粒中进行界面能量调节
Jiang Ming1,2, Xusheng Wang1,2, Hongxin Zhang1,2
1Department of Chemistry, College of Smart Materials and Future Energy, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University; Shanghai Academy of Natural Sciences (SANS), Shanghai 200433, P. R. China.
Accounts of chemical research
|January 16, 2026
概括
用兰化物添加的升级转化纳米粒子 (UCNPs) 提供先进的生物医学成像. 一种新的层次方法精确地控制了用于增强发光和新型应用的接口.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学光学 生物医学光学
背景情况:
- 添加兰胺的升级转换纳米粒子 (UCNPs) 将近红外 (NIR) 光转换为更高能量的辐射,由于低自发光和深层组织透,非常适合生物医学用途.
- 与表面相关的火效应和传统核心外结构中缺乏原子级精度限制了UCNP的效率和应用范围.
- 精确控制界面能量传输对于复杂成像和传感等先进的UCNP应用至关重要.
研究的目的:
- 为制造多层UCNP引入一个单一的连续层次层次 (SLBL) 策略,以原子级精度.
- 展示"接口能量调整"的概念,以提高UCNP性能和新功能.
- 探索精确设计的UCNP在多重光遗传学,人类视觉和NIR-II生物成像中的潜力.
主要方法:
- 开发了一种多功能的一连续层次 (SLBL) 策略,用于控制UCNP贝的表生长.
- 利用精确的反应动力学来操纵的生长,并实现对纳米结构制造的原子级控制.
- 工程化多层UCNP系统,采用特定的兰化物剂安排,以量身定制的光学特性.
主要成果:
- 从单个纳米颗粒获得直角三色向上转换发光,使多重光遗传神经调节和NIR光视觉成为可能.
- 通过精确的多层工程设计,设计了新的Er3+,Tm3+和Ho3+敏感的UCNP,具有高效的NIR-II (1000-2000nm) 激发.
- 在实体中展示了包括实时比度生物传感,高通量多重成像和动态可视化在动物模型中的应用.
结论:
- 该SLBL战略为UCNP界面能量传输提供了前所未有的控制,将界面转化为可编程的能源景观.
- 精确设计的多层UCNPs解锁了先进的生物医学应用,包括NIR-II窗口中的多重成像和传感.
- 这项工作为下一代可编程光子纳米设备的合理设计框架提供了前沿的生物医学研究.
相关概念视频
Energy Budgets and Reproductive Strategies
Organisms must balance energy intake with the energy required for growth, maintenance, and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species reproduce only once in their lifetime, often investing most available resources into that single reproductive event. Iteroparous species, by contrast, reproduce multiple times over their lifetimes, typically allocating fewer resources to any single...
Bioreactor Controls-III
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Designing Growth Media for Bioreactors
Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
Methods of Medium Optimization
Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
Scale-Up Processes
The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Upstream Processing
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...


