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Updated: Jan 18, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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获得的非允许性BM微环境会影响HSC的增殖和维护以及HSCT后的B细胞发展

Melanie de Gier1, Jakov Korzhenevich2, Franziska Schmidt2

  • 1LUMC, Leiden, Netherlands.

Blood advances
|January 16, 2026
PubMed
概括

造血干细胞移植 (HSCT) 可以导致由于骨髓微环境缺陷而导致B细胞缺乏. 这项研究揭示了获得的,永久的B细胞损失与减少CXCL12在介质细胞 stromal细胞,损害HSC功能.

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