在固体器官移植中,对强基洛伊德 (Strongyloides stercoralis) 的捐赠者查失败
Emerging infectious diseases
|January 16, 2026
概括
源自捐赠者的Strongyloides stercoralis感染可能发生在移植接受者身上. 追溯测试显示,尽管最初的血清学结果是负的,但传播仍在继续,这突显了查的局限性和监测需求.
科学领域:
- 传染性疾病 传染性疾病
- 移植免疫学 移植免疫学
- 寄生虫学的寄生虫学
背景情况:
- 斯特朗基洛伊德 (Strongyloides stercoralis) 是一种土壤传播的虫,有可能导致慢性和高感染综合征.
- 接受脏移植的接受者免疫受损,增加了对机会性感染的敏感性,包括寄生虫感染.
- 在固体器官移植中,来自捐赠者的感染构成重大风险.
研究的目的:
- 在移植中报告Strongyloides stercoralis从供体传播到受体的病例.
- 为了突出标准血清学查Strongyloides stercoralis在器官捐献者的局限性.
- 强调加强对危险移植群体寄生虫感染的监测协议的重要性.
主要方法:
- 病例报告:两名脏移植接受者患有Strongyloides stercoralis感染.
- 对供体血清检测的审查,包括最初的负结果和随后的回顾性检测.
- 对移植后结果的临床和实验室数据分析.
主要成果:
- 在移植接受者中确认了两例来自供体的Strongyloides stercoralis感染病例.
- 供体样本的初始血清测试对Strongyloides stercoralis抗体呈阴性.
- 对供体样本的回顾性测试证实了寄生虫的传播.
结论:
- 在器官捐献者中,标准血清查Strongyloides stercoralis可能不足以排除传播.
- 针对性的查协议和加剧的临床怀疑对于那些面临Strongyloides stercoralis感染风险的人群至关重要.
- 密切的移植后监测对于及时检测和管理来自供体的寄生虫感染至关重要.
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