随机双盲住院患者研究无质饮食对精神分裂症患者的负面症状
Deanna L Kelly1, Christopher M Lee2, Gopal Vyas3
1Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Schizophrenia research
|January 16, 2026
概括
一种无质饮食 (GFD) 在精神分裂症患者的消极症状中表现出适度的改善,这些患者有炎症和高抗 gliadin 抗体 (AGA IgG+). 这种饮食干预也减少了特定代谢物,增加了脑血流 (CBF).
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 对于精神分裂症和相关疾病 (SRD) 的负面症状,没有FDA批准的治疗方法.
- 一小组SRD患者有系统/中心炎症和高抗素免疫球蛋白G抗体 (AGA IgG+) 可能受益于无质饮食 (GFD).
研究的目的:
- 调查GFD在改善SRD患者的负面症状中的有效性,这些患者的AGA IgG+水平升高.
- 探索GFD对金林途径代谢物,炎症标记物,脑血流 (CBF) 和神经化学的影响.
主要方法:
- 一个为期五周的,双盲,随机的安慰剂控制住院试验,将GFD与含质饮食 (GCD) 进行比较.
- 参与者 (N=39) 患有SRD和高AGA IgG+.
- 主要结局:通过临床评估采访负面症状动机和快乐 (CAINS MAP) 尺度测量负面症状.
主要成果:
- 与GCD相比,GFD与CAINS MAP得分的适度下降有关 (p=0.035).
- GFD导致氨酸 (KYNA) 和氨水平降低 (p<0.005).
- 在GFD组中观察到CBF和前额总肌酸的增加;认知仍然不受影响.
结论:
- 初步数据表明,GFD可能会在AGA IgG+ SRD亚组中适度改善体验性负面症状.
- GFD可能会减少 kynurenine 途径代谢物,并增加 CBF.
- 需要进行更大,更长的研究来证实GFD在这种特定的SRD人群中对负面症状的疗效.
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