肠道微生物组-代谢组合探索Naoxintong囊对阿托瓦斯塔丁在改善高脂血症方面的辅助作用:一项随机对照试点研究
Wei-Jian Zhang1, Jian Wang2, Mei-Yan Liao2
1Department of Neurosurgery, First People's Hospital of Foshan, Foshan, 528010, Guangdong, China; Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
将Naoxintong囊 (NXT) 添加到阿托瓦斯塔丁显著改善脂质概况,并减少高脂血症患者的炎症. 这种组合疗法可以通过改变肠道微生物群和代谢途径来改善心血管健康.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 纳奥辛通囊 (NXT) 是一种传统的中医药,与西方医学一起用于动脉样硬化心血管疾病.
- 超脂血是心血管疾病的重要危险因素.
研究的目的:
- 为了研究在高脂血症患者中添加NXT到他类药物治疗的效果.
- 探索这种组合治疗的潜在机制.
主要方法:
- 32名高脂血症患者被随机分为两个组:单独使用阿托瓦斯塔丁和阿托瓦斯塔丁加NXT12周.
- 主要结局:脂肪代谢的变化. 二次结果:炎症,内皮功能,肝功能,心肌酶.
- 进行了微生物组和代谢学分析以阐明机制.
主要成果:
- 与单独的阿托瓦斯塔丁相比,组合疗法显示LDL-C和TG的显着更大降低,HDL-C的更大增加.
- 添加NXT导致炎症标志物 (IL-6,TNF-α) 和心肌损伤生物标志物 (LDH,CK-MB) 的显著减少.
- 肠道细菌 (例如,链球菌,Veillonella) 和代谢途径 (例如,酸盐循环,脂质代谢) 与增强的治疗效果有关.
结论:
- 将NXT添加到阿托瓦斯塔丁增强了对超脂血症的治疗效果.
- 增强的疗效可能归因于肠道微生物群组成和血代谢物丰度的变化.
- 这项研究为NXT在联合超脂血症治疗中的机制提供了新的见解.
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