饮食中的 (多) 作为自然杀手细胞功能和免疫发生的调节剂:从分子途径到临床证据
Asmita Acharya1, Giuseppe Mazzola2, Mariangela Rondanelli2
1Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Human Nutrition, Università degli Studi di Milano, Milan, Italy.
概括
饮食中的多可以增强自然杀手 (NK) 细胞的功能,并对抗与衰老相关的免疫衰退. 需要进行进一步的临床试验,以优化其用于健康衰老的使用.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 衰老导致免疫衰老,其特点是自然杀手 (NK) 细胞功能下降和慢性炎症,增加疾病风险.
- 饮食中的多在抵消与年龄相关的免疫衰退和增强免疫反应方面表现有前途.
研究的目的:
- 系统地审查有关饮食中的多醇如何影响NK细胞可塑性和免疫发生的证据.
- 探索聚醇作为健康衰老干预措施的潜力.
主要方法:
- 按照PRISMA指导方针进行系统性审查,包括对多干预和NK细胞结果的人类,动物和体外研究.
- 从2010年到2025年6月,搜索了主要的数据库 (PubMed,Embase,科学网,Scopus,柯克兰图书馆).
- 评估偏差风险使用已建立的工具进行临床前,临床和体外研究.
主要成果:
- 19项研究证实,多 (例如,白醇, катехин, 氨酸) 提高NK细胞激活,细胞毒性和先天免疫功能.
- 聚醇调节了T细胞子集,并在各种衰老模型中改善了免疫反应.
- 在体外研究中偏差很低;在体外研究中由于报告限制,一些担忧.
结论:
- 聚醇显示出显著的免疫调节作用,增强NK细胞功能和减轻免疫衰变.
- 临床前发现是有希望的,但临床试验对于解决个性化策略的生物可用性和可变性至关重要.
- 需要进一步的研究来将多的好处转化为老年人群免疫健康的有效干预措施.
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