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孕期PBDE度和青少年的功能性连接:家庭研究

Jonathan Dudley¹, Kimberly Yolton², Alex D Edmondson³

¹Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

International journal of hygiene and environmental health

|January 16, 2026

概括

产前暴露于多二乙烯 (PBDE) 与青少年大脑连接的改变有关. 这项研究发现,更高的妊娠期PBDE水平与视觉皮层连接性降低有关,影响神经行为结果.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
发育毒理学发展毒理学

背景情况:

怀孕期间暴露于常见的阻燃剂聚二乙烯 (PBDE) 疑似会损害儿童的神经发育.
通过PBDE影响发育中的大脑的确切机制仍然不完全理解.

研究的目的:

为了研究产前PBDE血清度与青少年内在功能性大脑连接之间的联系.
探索功能性连接是否调解妊娠期PBDE暴露和神经行为结果之间的关系.

主要方法:

在怀孕期间测量了母亲血清PBDE度 (五种同源,5BDE).
在12岁时使用高分辨率MRI (解剖学和静止状态fMRI) 来评估功能连接.
用自我和照顾者报告来评估神经行为结果,并进行调解分析.

主要成果:

较高的孕期BDE-153度与左下侧脑后皮层的局部连接性增加相关.
妊娠期PBDE水平升高 (BDE-28, -47, -99, -100, 5BDE) 与初级视觉皮层的全球连接性下降有关.
功能连接模式显著介导了5BDE暴露与神经行为结果之间的关联.

结论:

孕期PBDE暴露与青少年初级视觉皮层的功能连接性下降有关.
改变的大脑连接调解了产前PBDE暴露与12岁时神经行为结果之间的联系.
研究结果表明,PBDE在发育过程中会破坏全球大脑网络中的视觉信息处理.

关键词:

青少年是一个青少年.功能性的连接性功能性的连接性功能性磁共振成像技术功能性磁共振成像技术孕期的孕期的调解调解是一种调解.聚化乙烯乙阻燃剂是一种阻燃剂.视觉皮层的视觉皮层.

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