相关实验视频
Updated: Jan 18, 2026
10:28
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
16.3K
糖尿病前期正常体重成年人的新陈代谢和身体组成变化:基于DEXA的分析分析
Sami Bahçebaşı1, Banu Açmaz1, Ahmet Savranlar2
1Internal Medicine Department, Kayseri City Hospital, Kayseri, Türkiye.
概括
正常体重女性的糖尿病前期与中心脂肪积累有关,以安卓/肌肉脂肪比率表示. 在男性中,功能受损和干部脂肪与糖尿病前期有关,这凸显了身体成分查的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 研究健康和糖尿病前期正常体重 (BMI 18.5-24.9 kg/m2) 个体之间的差异.
- 专注于中央脂肪分布及其代谢影响.
研究的目的:
- 分析正常体重糖尿病前期患者与健康个体的临床,生化和身体组成变化.
- 确定正常体重成年人糖尿病前期体脂分布的预测值.
主要方法:
- 招募了60名参与者 (30名糖尿病前期患者,30名健康患者).
- 使用双能X射线吸收计 (DEXA) 进行了临床评估和身体组成分析.
主要成果:
- 在女性中,Android-to-gynoid脂肪比率独立预测了糖尿病前期 (p=0.014).
- 在男性中,降低的淋巴膜过率 (GFR) 和升高的肌素表明功能受损 (p=0.008,p=0.019).
- 中部脂肪分布,特别是干脂肪,与禁食葡萄糖相关,尽管这在年龄调整后失去意义.
结论:
- 正常体重女性的糖尿病前期与中心肥胖 (较高的安卓/肌肉脂肪比率) 和葡萄糖代谢受损有关.
- 在男性中,中央脂肪分布与葡萄糖代谢有关,但年龄可能会调节这种关联. 观察到早期的功能障碍 (降低的EGFR).
- 使用DEXA衍生脂肪比率的身体组成查可以识别高风险的正常体重个体,用于预防性干预.
相关概念视频
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
01:22Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
01:29Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
01:36Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K
01:16Insulin: Dosing Regimen and Adverse Effects
689
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
689
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K